Yusuke is an artist, he looks at life for all its hidden flaws and beauties. While he can often come off to others as pompous or arrogant he is actually deeply wise and cares for his friends in a very paternal way. 

His voice should be in a mostly low range. He usually has an air of slight arrogance around him (emphasis on slight) and constantly sounds like an artist describing his next great work.

PLEASE NOTE: Although Yusuke's lines sound insulting sometimes he rarely ever speaks with actual venom. He is just incredibly blunt and not great at communication. I've seen some auditions with people taking the first line as bile-filled insult and this should not be how it is read.

You can look at the game's dub actor, Matthew Mercer, for reference.

(Yusuke has one line in this first episode. I have added an extra line so I can still get a decent impression of the voice. He will appear more in later episodes.)