A geneticist of half Irish/Hispanic descent in his late 20s.

In the year 2099, geneticist Miguel O'Hara worked on recreating the powers of the original Spider-Man for Alchemax, but refused to experiment on humans at such an early stage. Tyler Stone, Miguel's boss in Alchemax, spiked a drug on his drink to keep him loyal and allow the experimentation. To overcome the effect of the drug, Miguel spliced his own DNA and got spider-like powers. Miguel became the new Spider-Man to fight crime and Tyler Stone's corruption.

One day, he was sucked into Earth-616, Peter Parker's universe, and befriended him along with Miles Morales. He and Miles encourage Parker to come back as Spider-Man and stop Kingpin.