Neurodegenerative diseases impair cognitive, sensory, and motor functions, and are among the leading causes of disability and death worldwide.

The timely and accurate detection of neurodegeneration, including Alzheimer's disease, is fundamental to effective intervention and management of patients to preserve brain health, but remains challenging.

A structured approach to patient assessment and thorough probing of cognitive complaints can reveal a pattern of "red flag" symptoms that potentially signify early neurodegeneration.